Welcome to KOBAS 2.0

KOBAS 2.0 is an update of KOBAS (KEGG Orthology Based Annotation System). Its purpose is to identify statistically enriched related pathways and diseases for a set of genes or proteins, using pathway and disease knowledge from multiple commonly used databases.

Updates of KOBAS 2.0

KOBAS 2.0 includes KEGG PATHWAY, PID Curated, PID BioCarta, PID Reactome, BioCyc, Reactome and Panther pathway databases.
KOBAS 2.0 includes KEGG DISEASE, GAD, FunDO, OMIM and NHGRI human disease databases.
KOBAS 2.0 can annotate queries to both KEGG GENES and KEGG Orthology (KO) terms.
KOBAS 2.0 can parse and annotate BLAST result (in tabular format) produced from a set of DNA / protein sequences.

Versions of KOBAS 2.0

Current KOBAS 2.0 programs were updated on February 8th, 2012. (New features)
Current KOBAS 2.0 backend database was updated on February 8th, 2012. All dependent files from other databases were up to date on February 8th, 2012.
Version History

How to Cite KOBAS 2.0

Xie, C., Mao, X., Huang, J., Ding, Y., Wu, J., Dong, S., Kong, L., Gao, G., Li, C. and Wei, L. (2011) KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res, 39, W316-322. [Abstract] [Full Text]

Other references

Mao, X., Cai, T., Olyarchuk, J.G. and Wei, L. (2005) Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics, 21, 3787-3793. [Abstract] [Full Text]
Wu, J., Mao, X., Cai, T., Luo, J. and Wei, L. (2006) KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res, 34, W720-724. [Abstract] [Full Text]