Welcome to KOBAS 2.0

KOBAS 2.0 is an update of KOBAS (KEGG Orthology Based Annotation System). It can identify statistically significantly enriched pathways, human diseases, and functional terms for an input set of genes using biological knowledge from well-known pathway databases, disease databases, and Gene Ontology.


Updates of KOBAS 2.0

Annotate + Identify is a new program of KOBAS 2.0. It combines Annotate and Identify.
KOBAS 2.0 integrates Gene Ontology.
KOBAS 2.0 integrates OMIM, KEGG DISEASE, FunDO, GAD, and NHGRI GWAS Catalog disease databases.
KOBAS 2.0 integrates KEGG PATHWAY, PID, BioCarta (from PID), Reactome, BioCyc, and PANTHER pathway databases.
KOBAS 2.0 can annotate queries to either KEGG genes or KEGG Orthology (KO) terms.
KOBAS 2.0 can parse and annotate BLAST result (in tabular format) of a set of nucleotide / protein sequences.

Versions of KOBAS 2.0

Current KOBAS 2.0 programs were updated on January 26th, 2015. (New features)
Current KOBAS 2.0 backend databases were updated on February 28th, 2015. All dependent files from other databases were up to date on February 28th, 2015, except for GAD (which was up to date on March 20th, 2014).
Version history

How to Cite KOBAS 2.0

Xie, C., Mao, X., Huang, J., Ding, Y., Wu, J., Dong, S., Kong, L., Gao, G., Li, C. and Wei, L. (2011) KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res, 39, W316-322. [Abstract] [Full Text]

Other References

Mao, X., Cai, T., Olyarchuk, J.G. and Wei, L. (2005) Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics, 21, 3787-3793. [Abstract] [Full Text]
Wu, J., Mao, X., Cai, T., Luo, J. and Wei, L. (2006) KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res, 34, W720-724. [Abstract] [Full Text]