KOBAS web server provides KOBAS (KEGG Orthology-Based Annotation System) functionalities on the web. Besides, it has two helpful management uitilites for user with large set of data to analyze.

All user input and output are strictly confidential. The results of guest users are kept on the server for 7 days, whereas for the registered users (free) the results are kept for 6 months.

Tools


 Annotate a set of sequences with KO terms.
  • Given a set of nucleotide or protein sequences in FASTA format, KO terms are assigned based on sequence similarity to entries in KEGG GENES. This analysis may require several hours, depending on the number and length of sequences you submitted.
  • Given a list of sequence identifiers of popular databases, KO terms are assigned based on cross-database links in KEGG GENES.
Identify the frequently occurring or statistically significantly enriched pathways of the queried sequences against the background. The input is the output from KO annotation.
Management utilities
Free registration will give users following utilities that will be helpful to management large set of data to analyze:
  • User Space Allows users to store sequences and analysis results hierarchically on KOBAS server (kept for 6 months). Data stored on the server can be used as input for subsequent analysis.

  • Analysis History Shows the complete list of submitted job information, including input and output, elapsed time, and status, etc.
Tutorial
A step-by-step tutorial with screenshot to illustrate the use of the web server.
Citing
Mao X., Cai T., Olyarchuk J.G., Wei L. (2005) Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary, Bioinformatics, 21(19):3787-3793. [Full Text]
Wu J., Mao X., Cai T., Luo J., Wei L. (2006) KOBAS server: a web-based platform for automated annotation and pathway identification, Nucleic Acids Res, 34 (Web Server issue):W720-724. [Full Text]
Feedback
Don't hesitate to write to us if you have any question. We will be grateful if you find any bug and report us.
 

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